The Chicago PD series DVD follows District 21 of the Chicago Police Department, which is made up of two distinctly different groups: the uniformed cops and the Intelligence Unit.

The team responds to the shooting of a 5-year-old girl and they must work the case while facing new obstacles that come from the heightened attention on police reform. Atwater is targeted by a group of officers who want to hurt him for standing against the blue wall. Voight questions whether he's cut out for a new form of policing as he manages oversight from the CPD's deputy superintendent.

When the son of an influential former officer is implicated in a murder, Moore pressures Voight to charge him quickly. The stakes are raised in Atwater's fight against the blue wall after patrol officers stop responding to his team's calls.